Dhékstrométorfan

Dhékstrométorfan
Jeneng sistematis (IUPAC)
	(4bS,8aR,9S)-3-Methoxy-11-methyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene
Data klinis
Jeneng dagang	Robitussin, Delsym, DM, DexAlone, Duract
AHFS/Drugs.com	Monograph
MedlinePlus	a682492
Kat. kehamilan	A(AU) C(US)
Status hukum	Pharmacy Only (S2) (AU) OTC (CA) GSL (UK) OTC (US)
Kamungkinan katergantungan	Rendah
Rute	Oral
Pharmacokinetic data
Bioavailabilitas	11%
Métabolisme	Hati enzymes: major CYP2D6, minor CYP3A4, and minor CYP3A5
Wektu paro	2-4 jam (extensive metabolisers); 24 jam (poor metabolisers)
Èkskrèsi	Ginjal
Pangenal
Nomor CAS	125-71-3
Kode ATC	R05DA09
PubChem	CID 15978238
Ligan IUPHAR	6953
DrugBank	DB00514
ChemSpider	13109865Cithakan:Chemspidercite
UNII	7355X3ROTSCithakan:Fdacite
KEGG	D03742 [kegg]
ChEBI	CHEBI:4470
ChEMBL	CHEMBL52440
Data kimia
Formula	C18H25NO
Massa mol.	271.40 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1 ; Key:MKXZASYAUGDDCJ-NJAFHUGGSA-N ;
Data fisik
Titik lebur	111 °C (232 °F)

Dèkstrometorfan ya kuwi sawijining obat kanggo nambani lara watuk. Watuké jinis watuk garing amarga infèksi tertamtu. Obat iki asring dicekak DM.

Dhosis

Dhosis nalika migunakaké obat iki ya iku:

Dextromethorphan ing permen pelega tenggorokan
- Dhiwasa: 5-15 mg saben 2-4 jam.
- Bocah 6-12 taun: 5-15 mg saben 2-6 jam.
- Bocah 4-6 taun: 5 mg saben 4 jam.

Dextromethorphan sirop
- Dhiwasa: 30 mg, saben 6-8 jam.
- Bocah 6-12 taun: 7 mg saben 4 jam, atau 15 mg saben 6-8 jam.
- Bocah 4-6 taun: 3,5 mg saben 4 jam, atau 7,5 mg saben 6-8 jam.

Dextromethorphan tablèt
- Dhiwasa: 60 mg saben 12 jam.
- Bocah 6-12 taun: 30 mg saben 12 jam.
- Bocah 4-6 taun: 15 mg saben 12 jam.^[3]

Cara nyimpen

Obat iki prayogané disimpen ana ing hawa ruwang.^[4] Obat iki diadohaké saka sunaring srengéngé langsung lan papan panggonan sing ampeg. Dékstrometorfan aja didèlèh ing kolah utawa jedhing lan lemeri ès utamané ing freezer. Saben mèrék nduwéni paugeran anggoné nyimpen obat iki. Gatèkaké prèntah nyimpen ing wungkusé.

Dékstrometorfan iki luwih becik diadohaké marang obat liya utamané sing ambuné sengak. Adohaké obat iki marang bocah cilik lan uga kewan klangenan. Aja mbuwang obat iki menyang pecerèn kolah. Sadurungé migunakaké Dékstrometorfan, kudu ndeleng tanggal kadaluwarsa ing ana ing wungkusé. Menawa wis kliwat tanggal kadaluwarsa, luwih becik diguwak. Anggoné mbuwang iki ora kena sembrana.

Èfèk samping

Èfèk samping nalika migunakaké obat iki ya kuwi:

Mumet
Mukok
Dhegelen
Sedasi^[5]

Pustaka

↑ Kukanich, B.; Papich, M. G. (2004). "Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs". Journal of Veterinary Pharmacology and Therapeutics. 27 (5): 337–41. doi:10.1111/j.1365-2885.2004.00608.x. PMID 15500572.
↑ "Balminil DM, Benylin DM (dextromethorphan) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Dibukak ing 15 April 2014.
↑ "Dextromethorphan". Alodokter. 2014-11-12. Dibukak ing 2020-09-18.
↑ "Dextromethorphan : Fungsi, Dosis, Efek Samping, Cara Pakai". Hello Sehat (ing basa Indonesia). 1969-12-31. Dibukak ing 2020-09-19.
↑ "Dextromethorphan | Fungsi, Cara Pemakaian, Dosis, Efek Samping". SehatQ (ing basa Indonesia). Diarsip saka sing asli ing 2020-10-02. Dibukak ing 2020-09-18.

[pmid15500572-1] Kukanich, B.; Papich, M. G. (2004). "Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs". Journal of Veterinary Pharmacology and Therapeutics. 27 (5): 337–41. doi:10.1111/j.1365-2885.2004.00608.x. PMID 15500572.

[MSR-2] "Balminil DM, Benylin DM (dextromethorphan) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Dibukak ing 15 April 2014.

[3] "Dextromethorphan". Alodokter. 2014-11-12. Dibukak ing 2020-09-18.

[4] "Dextromethorphan : Fungsi, Dosis, Efek Samping, Cara Pakai". Hello Sehat (ing basa Indonesia). 1969-12-31. Dibukak ing 2020-09-19.

[5] "Dextromethorphan | Fungsi, Cara Pemakaian, Dosis, Efek Samping". SehatQ (ing basa Indonesia). Diarsip saka sing asli ing 2020-10-02. Dibukak ing 2020-09-18.

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