Triazavirin

Saka Wikipédia Jawa, bauwarna mardika basa Jawa
Triazavirin
Jeneng sistematis (IUPAC)
2-methylsulfanyl-6-nitro[1,2,4]triazolo[5,1-c][1,2,4]triazin-7(4H)-one
Data klinis
Kat. kehamilan ?
Status hukum ? (US)
Pangenal
Nomor CAS 928659-17-0 ☒N
Kode ATC ?
PubChem CID 3113817
ChemSpider 2367718
Data kimia
Formula C5H4N6O3S 
Massa mol. 228.189
SMILES eMolecules & PubChem

Triazavirin (TZV, Riamilovir) yaiku antivirus analog Nukleotida kang awale dikembangake ning negara Ruslan kang uwis nunjukake khasiat kangge penyakit Influenza A lan B, kalebu strain H5N1.[1][2][3][4] Miturut riset, Triazavirin dinuga angsal nyudai penyakit flu lan uga komplikasi penyakit sing semaceme.[5] Antivirus iki dhuwe inti saka novel triazolotriazine kang ngewakili kelas struktural anyar saka ubat-ubatan antivirus non-nukleosida.[6]

Kagunaan[besut | besut sumber]

Triazavirin awitane dikembangake ning Akademi Ilmu Ruslan, Universitas Federal Ural ing Ekaterinburg, Ruslan, sing dikembangake kanggo ngatasi wabah virus Avian Influenza (H5N1), banjur amarga ana sawetara persamaan karo koronavirus, para peneliti rumangsa perlu nyoba kanggo nliti khasiat obat kasebut ing pasien korona.[6][7][8] Umume penelitian ditindakake kanggo nguji kegiatan reaksi anti-influenza.[7][8]

Referensi[besut | besut sumber]

  1. Kiselev, O. I.; Deeva, E. G.; Mel'nikova, T. I.; Kozeletskaia, K. N.; Kiselev, A. S.; Rusinov, V. L.; Charushin, V. N.; Chupakhin, O. N. (2012-11). "[A new antiviral drug Triazavirin: results of phase II clinical trial]". Voprosy Virusologii. 57 (6): 9–12. ISSN 0507-4088. PMID 23477247. {{cite journal}}: Check date values in: |date= (pitulung)
  2. Vincent, Martin J.; Bergeron, Eric; Benjannet, Suzanne; Erickson, Bobbie R.; Rollin, Pierre E.; Ksiazek, Thomas G.; Seidah, Nabil G.; Nichol, Stuart T. (2005-08-22). "Chloroquine is a potent inhibitor of SARS coronavirus infection and spread". Virology Journal. 2: 69. doi:10.1186/1743-422X-2-69. ISSN 1743-422X. PMC 1232869. PMID 16115318.
  3. Karpenko, Inna; Deev, Sergey; Kiselev, Oleg; Charushin, Valerey; Rusinov, Vladimir; Ulomsky, Eugeney; Deeva, Ella; Yanvarev, Dmitry; Ivanov, Alexander (2010-05). "Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication". Antimicrobial Agents and Chemotherapy. 54 (5): 2017–2022. doi:10.1128/AAC.01186-09. ISSN 1098-6596. PMC 2863629. PMID 20194696. {{cite journal}}: Check date values in: |date= (pitulung)
  4. Shvetsov, Alexey V.; Zabrodskaya, Yana A.; Nekrasov, Peter A.; Egorov, Vladimir V. (2018-07-27). "Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure". Journal of Biomolecular Structure and Dynamics. 36 (10): 2694–2698. doi:10.1080/07391102.2017.1367329. ISSN 0739-1102. PMID 28828928.
  5. "China tests Russian anti-viral drug which might treat coronavirus as Moscow warns of possible 'mass outbreak'". RT International (ing basa Inggris). Dibukak ing 2020-05-03.
  6. a b Rusinov, Vladimir L.; Sapozhnikova, Irina M.; Ulomskii, Evgeny N.; Medvedeva, Natalia R.; Egorov, Vladimir V.; Kiselev, Oleg I.; Deeva, Ella G.; Vasin, Andrey V.; Chupakhin, Oleg N. (2015-03-01). "Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins". Chemistry of Heterocyclic Compounds (ing basa Inggris). 51 (3): 275–280. doi:10.1007/s10593-015-1695-4. ISSN 1573-8353.
  7. a b Loginova SIa, Borisevich SV, Maksimov VA, et al. Antibiot Khimioter. 2007;52(11-12):18‐20.
  8. a b SIa, Loginova; Sv, Borisevich; Va, Maksimov; Vp, Bondarev; Sk, Kotovskaia; Vl, Rusinov; Vn, Charushin (2007). "[Investigation of Triazavirin Antiviral Activity Against Influenza A Virus (H5N1) in Cell Culture]". Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (ing basa Inggris). PMID 19275052. Dibukak ing 2020-05-03.