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Naraguna:Ariyanto/Senna glycoside

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Ariyanto/Senna glycoside
Data klinis
Jeneng dagang Ex-Lax, Senokot, and others[1]
AHFS/Drugs.com Monograph
MedlinePlus a601112
Data lisènsi US Daily Med:link
Kat. kehamilan ?(AU) ?(US) C[1]
Status hukum OTC (US)
Rute By mouth (PO), rectal (PR)
Pangenal
Kode ATC A06AB06
ChemSpider noneCithakan:Chemspidercite
Data kimia
Formula C42H38O20 
Massa mol. 862.75

Senna glikosida, uga dikenal minangka sennosida utawa senna, minangka obat sing digunakake kanggo ngobati sembelit lan ngilangi usus gedhe sadurunge operasi. [1] [2] Obat dijupuk saka cangkeme utawa liwat rektum . [3] Biasane wiwit makarya sajrone sawetara menit nalika diwenehi rektum lan sajrone rolas jam nalika diwenehake dening cangkem. [4] Iku laxative sing luwih lemah tinimbang bisacodyl utawa minyak castor .

Efek samping sing umum saka senna glikosida kalebu kram ing weteng. [4] Ora disaranake kanggo nggunakake jangka panjang, amarga bisa nyebabake fungsi usus utawa elektrolit sing kurang apik . [1] Sanajan ora ana ditemokake, mula nggunakake nalika nyusoni, panggunaan kasebut ora biasane disaranake. Ora biasane dianjurake ing bocah-bocah. Senna bisa ngganti urin dadi warna sing rada abang. Turunan senna minangka jinis julap stimulasi lan jinis antigen . Nalika mekanisme tumindak kasebut ora jelas, senna dikira tumindak kanthi nambah sekresi cairan ing jero lan kontraksi usus gedhe.

Iki ana ing Organisasi Organisasi Kesehatan Dunia, Organisasi Perusahaan Penting, sing paling aman lan paling efektif sing dibutuhake ing sistem kesehatan . [5] Kasedhiya minangka obat umum lan cukup murah. [1] [3] Biaya Grosir ing jagad berkembang sekitar 0,01 USD saben pil. [6] Sennosida asale saka klompok tanduran Senna . [4] Ing wangun tanduran, wis paling ora digunakake wiwit taun 700an. [7] Ing taun 2016, yaiku obat kaping 287 sing paling diresepake ing Amerika Serikat sing luwih saka siji yuta resep. [8] Iki didol miturut pirang-pirang jeneng merek kalebu Ex-Lax lan Senokot.

Panggunaan medis

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Senna digunakake kanggo constipation episodic lan kronis sanajan ana bukti-bukti berkualitas tinggi kanggo ndhukung panggunaan kasebut kanggo tujuan kasebut. [2] Bisa uga digunakake kanggo mbantu ngevakuasi usus sadurunge operasi utawa pemeriksaan rektum utawa colonic invasi. [9] [10]

Administrasi

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Sampeyan kudu dijupuk sapisan dina nalika turu. [10] [11] Produk senna lisan biasane ngasilake gerakan usus sajrone 6 nganti 12 jam. Suppositori rektektual tumindak sajrone rong jam. [12]

Contraindications

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Miturut Komisi E senna dikontraindikasi ing kasus alangan usus, inflamasi usus akut (umpamane, penyakit Crohn ), kolitis ulseratif, apendisitis, lan nyeri weteng sing ora dingerteni. [9]

Senna dianggep kontraindikasi ing wong sing duwe alergi sing didokumentasikake kanggo ana anthraquinones . Alergi kaya kasebut langka lan biasane diwatesi reaksi dermatologis saka abang lan gatal. [9]

Efek sing ala

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Efek sing ala biasane diwatesi karo reaksi gastrointestinal lan kalebu nyeri weteng utawa cramp, diare, mual, lan mutah. [9] Panganggone produk senna kanthi rutin bisa nyebabake pigmen warna coklat saka tembok kolonik internal sing katon ing kolonoskopi . Pigmasi abnormal iki dikenal minangka melanosis coli . [12]

Interaksi

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Senna glikosida bisa nambah keracunan digoxin ing pasien sing njupuk digoxin kanthi nyuda tingkat kalium serum, saéngga nambah efek digoxin. [13]

Mekanisme tumindak

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Produk risak senna tumindak langsung minangka iritasi ing tembok kolonis kanggo nyebabake sekresi cairan lan motilitas kolonis. [14]

Farmakologi

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Dheweke minangka turunan anthraquinone lan glikosida dimerik .   [ <span title="Material near this tag needs references to reliable medical sources. (January 2020)">rujukan medis</span> ]

Masyarakat lan budaya

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Formulir

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Senna minangka obat over-the-counter sing kasedhiya ing macem-macem formulasi, kalebu formasi oral (cairan, tablet, granular) lan suposititoral rektum. Produk senna diprodhuksi dening produsen obat umum kaya macem-macem jeneng merek. [10]

Jeneng merek

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Kekuwatan maksimal Ex-Lax, Ex-Lax, Geri-kot, GoodSense Senna Laxative, Lemak Senna Asli, Perdiem Overnight Relief, Senexon, Senna Lax, Senna Laxative, Senna maksimal, Pursennid, Senna Smooth, Senna-Gen, Senna-GRX, Senna-Lax, Senna-Tabs, Senna-Time, SennaCon, Senno, Senokot To Go, Senokot XTRA, Senokot, Kayam churna. [9]

Cathetan

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  1. ↑ a b c d e American Society of Health-System Pharmacists (January 1, 2008). "Senna". Drugs.com. Diarsip saka sing asli ing 6 September 2015. Dibukak ing 11 August 2015.
  2. ↑ a b Wald, A (January 2016). "Constipation: Advances in Diagnosis and Treatment". JAMA (Review). 315 (2): 185–91. doi:10.1001/jama.2015.16994. PMID 26757467.
  3. ↑ a b Hamilton, Richard J. (2010). Tarascon pharmacopoeia (édhisi ka-2010). Sudbury, Mass.: Jones and Bartlett. kc. 181. ISBN 9780763777685. Diarsip saka sing asli ing 2016-03-05.
  4. ↑ a b c Navti, Phyllis (2010). Pharmacology for pharmacy and the health sciences : a patient-centred approach. Oxford: Oxford University Press. kc. 337. ISBN 9780199559824. Diarsip saka sing asli ing 2016-03-05.
  5. ↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  6. ↑ "Senna". International Drug Price Indicator Guide. Dibukak ing 11 August 2015.
  7. ↑ Khare, C.P. (2004). Indian Herbal Remedies Rational Western Therapy, Ayurvedic and Other Traditional Usage, Botany. Berlin, Heidelberg: Springer Berlin Heidelberg. kc. 133. ISBN 9783642186592. Diarsip saka sing asli ing 2016-03-05.
  8. ↑ "The Top 300 of 2019". clincalc.com. Dibukak ing 22 December 2018.
  9. ↑ a b c d e Lexicomp Online, Lexi Drugs Online, Hudson, Ohio: Lexi-Comp, Inc.; April 17, 2014.
  10. ↑ a b c Drugs.com "Archived copy". Diarsip saka sing asli ing 2014-04-19. Dibukak ing 2014-04-17.{{cite web}}: CS1 maint: archived copy as title (link)
  11. ↑ Lexicomp Lexicomp Online, Lexi Drugs Online, Hudson, Ohio: Lexi-Comp, Inc.; April 17, 2014.
  12. ↑ a b McQuaid KR. Chapter 62. Drugs Used in the Treatment of Gastrointestinal Diseases. In: Katzung BG, Masters SB, Trevor AJ. eds. Basic & Clinical Pharmacology, 12e. New York, NY: McGraw-Hill; 2012. "Archived copy". Diarsip saka sing asli ing 2014-04-19. Dibukak ing 2014-04-18.{{cite web}}: CS1 maint: archived copy as title (link). Accessed April 18, 2014.
  13. ↑ "Senna: MedlinePlus Supplements". Diarsip saka sing asli ing 2015-04-06.
  14. ↑ Sharkey KA, Wallace JL. Chapter 46. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease. In: Brunton LL, Chabner BA, Knollmann BC. eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e. New York, NY: McGraw-Hill; 2011. "Archived copy". Diarsip saka sing asli ing 2014-04-19. Dibukak ing 2014-04-18.{{cite web}}: CS1 maint: archived copy as title (link). Accessed April 18, 2014.
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  • "Senna". Drug Information Portal. U.S. National Library of Medicine.
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