Kolésterol
| Kolésterol | |
|---|---|
 |
|
 |
|
|
(3β)-cholest-5-en-3-ol
|
|
|
Jeneng liya
(10R,13R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
|
|
| Identifikasi | |
| Nomor CAS | [57-88-5] |
| PubChem | |
| KEGG | D00040 |
| SMILES | C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C |
| InChI | 1/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 |
| Sifat | |
| Rumus molekul | C27H46O |
| Massa molar | 386.65 g/mol |
| Panampilan | white crystalline powder[1] |
| Densitas | 1.052 g/cm3 |
| Titik leleh |
148–150 °C[1] |
| Titik umob |
360 °C (decomposes) |
| Kelarutan dalam air | 0.095 mg/L (30 °C) |
| Kelarutan | soluble in acetone, benzene, chloroform, ethanol, ether, hexane, isopropyl myristate, methanol |
| Kejaba ditélakaké suwaliké, data ing ndhuwur kanggo ing suhu lan tekanan standar (25°C, 100 kPa) |
|
Kolesterol adalah metabolit yang mengandung lemak sterol[2] (Basa Inggris: waxy steroid) yang ditemukan pada membran sel dan disirkulasikan dalam plasma darah.[3] Yaiku sawijing lipid kang awujud molekul lemak utawa kang meh padha. Kolesterol yaiku jenis khusus lipid kang disebut steroid. Steroids yaiku lipid kang nduwéni struktur kimia khusus. Struktur iki asalé saka 4 ali-ali atom karbon.
Steroid liyané kalebu steroid hormon kayata kortisol, estrogen, lan testosteron. Nyatané,kabéh hormon steroid digawé saka owahan-owahan struktur dasar kimia kolesterol. Nalika gawé sawijiné molekul saka ngubahan molekul kang luwih gampang, para ilmuwan nyebut sintesis.
Hiperkolesterolemia tegesé bilih kadar kolesterol luwih dhuwur ing jero getih.
Kolesterol bisa digawé kanthi cara sintetik. Kolesterol sintetik saiki wiwit ditrepké ing teknologi layar lebar (billboard) sebagai alternatif LCD.[4]
Dhuwuré kadar kolestrol ing jero awak dadi pemicu metuné werna penyakit. Pola mangan sehat minangka faktor utama kanggo nyingkiri babagan kuwi. Ananging, ora kabéh kolestrol duwé dampak buruk kanggo awak. Namung kolestrol kang kalebu kategori LDL waé kang berakibat buruk éwondéné jenis kolestrol HDL minangka kolestrol kang bisa melarutkan kolestrol jahat ing jero awak. Batas normal kolesterol ing jero awak yaiku 160-200 mg. Kadar kolesterol kang dhuwur bisa dimudhunké nganggo simvastatin.[5]
[sunting] Cathetan suku
- ↑ a b Safety (MSDS) data for cholesterol. URL diaksès tanggal 2007-10-20
- ↑ (en)Michelle A, Hopkins J, McLaughlin CW, Johnson S, Warner MQ, LaHart D, Wright JD. (1993). Human Biology and Health. Englewood Cliffs, New Jersey, USA: Prentice Hall. ISBN 0-13-981176-1. OCLC 32308337.
- ↑ (en) Emma Leah (May 2009). "Cholesterol". Lipidomics Gateway. DOI:10.1038/lipidmaps.2009.3.
- ↑ Eric Pfanner. A place where cholesterol is welcome: in billboards. The New York Times edition in Süddeutsche Zeitung. Jan. 8, 2007.
- ↑ (en) Factor XIII. Wojewodzki Szpital Zespolony, University of Barcelona Faculty of Medicine, et al; Robert A Schwartz, Elzbieta Klujszo, et al.. URL diaksès tanggal 2010-04-29. Effects of other agents on FXIII, 4th paragraph
